Publications | CARsgen

Molecular Therapy

Sep 20, 2023

Expressing CXCR4 in CAR T cells Suppresses MDSCs Recruitment via STAT3/NF-κB/SDF-1α axis to enhance Anti-tumor Efficacy against Pancreatic Cancer

Ruixin Sun, Yansha Sun, Chuanlong Wu, Yifan Liu, Min Zhou, Yiwei Dong, Guoxiu Du, Hong Luo, Bizhi Shi, Hua Jiang, Zonghai Li

Journal of Hematology & Oncology

Sep 09, 2023

CT041 CAR T cell therapy for Claudin18.2-positive metastatic pancreatic cancer

Changsong Qi, Tong Xie, Jun Zhou, Xicheng Wang, Jifang Gong, Xiaotian Zhang, Jian Li, Jiajia Yuan, Chang Liu, Lin Shen

eClinicalMedicine

Aug 30, 2023

RUNX-3-expressing CAR T cells targeting glypican-3 in patients with heavily pretreated advanced hepatocellular carcinoma: a phase I trial

Qihan Fu, Yi Zheng, Weijia Fang, Qingwei Zhao, Peng Zhao, Lulu Liu, You Zhai, Zhou Tong, Hangyu Zhang, Meihua Lin, Xudong Zhu, Huamao Wang, Yumeng Wang, Zhen Liu, Daijing Yuan, Xuanwen Bao, Wanwan Gao, Xiaomeng Dai, Zonghai Li, Tingbo Liang

Cancer Communications

Jul 21, 2023

Combined local therapy and CAR-GPC3 T-cell therapy in advanced hepatocellular carcinoma: a proof-of-concept treatment strategy

Yaoping Shi, Donghua Shi, Jiachang Chi, Dan Cui, Xiaoyin Tang, Yan Lin, Siying Wang, Zonghai Li, Haojie Jin, Bo Zhai

Journal of Translational Medicine

Apr 12, 2023

FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer

Yifan Liu, Yansha Sun, Peng Wang, Songling Li, Yiwei Dong, Min Zhou, Bizhi Shi, Hua Jiang, Ruixin Sun, Zonghai Li

Biochemical Pharmacology

Apr 05, 2023

Expressing IL-15/IL-18 and CXCR2 improve infiltration and survival of EGFRvIII-targeting CAR T cells in breast cancer

Ruixin Sun, Yifan Liu, Chuanlong Wu, Min Zhou, Hong Luo, Guoxiu Du, Zhengyang Liu, Yansha Sun, Yiwei Dong, Jingwen Su, Mingliang Fan, Bizhi Shi, Hua Jiang, Zonghai Li

Molecular Therapy

Dec 15, 2022

Enforced expression of Runx3 improved CAR-T cell potency in solid tumor via enhancing resistance to activation-induced cell death

Yi Wang, Honghong Zhang, Guoxiu Du, Hong Luo, Jingwen Su, Yansha Sun, Min Zhou, Bizhi Shi, Henry Q X Li, Hua Jiang, Zonghai Li

Frontiers in Immunology

Aug 17, 2022

Long term complete response of advanced hepatocellular carcinoma to glypican-3 specific chimeric antigen receptor T-Cells plus sorafenib, a case report

Hongwei Sun, Chongyun Xing, Songfu Jiang, Kang Yu, Shengjie Dai, Hongru Kong, Yuepeng Jin, Yunfeng Shan, Wenjun Yang, Zhen Wang, Jun Xiao, Huamao Wang, Wei Wang, Zonghai Li, Keqing Shi

Molecular Therapy

Aug 04, 2022

Radiation enhances the efficacy of EGFR-targeted CAR T cells against triple-negative breast cancer by activating NF-κB/Icam1 signaling

Min Zhou, Muhua Chen, Bizhi Shi, Shengmeng Di, Ruixin Sun, Hua Jiang, Zonghai Li

Nature Medicine

May 09, 2022

Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results

Changsong Qi, Jifang Gong, Jian Li, Dan Liu, Yanru Qin, Sai Ge, Miao Zhang, Zhi Peng, Jun Zhou, Yanshuo Cao, Xiaotian Zhang, Zhihao Lu, Ming Lu, Jiajia Yuan, Zhenghang Wang, Yakun Wang, Xiaohui Peng, Huiping Gao, Zhen Liu, Huamao Wang, Daijing Yuan, Jun Xiao, Hong Ma, Wei Wang, Zonghai Li & Lin Shen